解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1929
更新日期:2014-05-01 00:00:00
abstract::Intramuscular myxoma (IM) is a benign intramuscular neoplasm composed of fibroblasts and abundant myxoid stroma. IMs most commonly affect larger skeletal muscles, while those affecting the oral and maxillofacial regions are rare, with a small number of documented cases in the available literature. The aim of the prese...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1955
更新日期:2014-05-01 00:00:00
abstract::The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1899
更新日期:2014-05-01 00:00:00
abstract::Ovarian cancer is the most fatal gynecological cancer, with a 5-year survival rate of only 30%. Lysophosphatidic acid (LPA), which possesses growth factor-like functions, is a major regulatory factor in the peritoneal metastasis of ovarian cancer. LPA stimulates the expression of numerous genes that are associated wit...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1926
更新日期:2014-05-01 00:00:00
abstract::Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1904
更新日期:2014-05-01 00:00:00
abstract::Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1898
更新日期:2014-05-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1954
更新日期:2014-05-01 00:00:00
abstract::The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1918
更新日期:2014-05-01 00:00:00
abstract::Extraskeletal myxoid chondrosarcoma (EMC) is a relatively rare but well-defined neoplasm. This report describes two patients, one with EMC of the buttock and one with EMC of the knee. The two cases presented with large lobed masses and long T1 and T2 signaling identified by magnetic resonance imaging (MRI). An enhance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1884
更新日期:2014-04-01 00:00:00
abstract::High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1851
更新日期:2014-04-01 00:00:00
abstract::The present study aimed to investigate the clinical outcomes of percutaneous transhepatic biliary drainage in patients with obstructive jaundice and identify potential predictors of patient survival. Clinical data from 102 patients (66 males and 36 females; median age, 63.50 years; range, 29-84 years) with a mean (± s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1860
更新日期:2014-04-01 00:00:00
abstract::The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1886
更新日期:2014-04-01 00:00:00
abstract::Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's Hospital. The clinicopa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1872
更新日期:2014-04-01 00:00:00
abstract::Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1853
更新日期:2014-04-01 00:00:00
abstract::The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1844
更新日期:2014-04-01 00:00:00
abstract::Human lactoferrin (hLF) is a multifunctional glycoprotein that inhibits cancer growth. However, the inhibitory effect of this glycoprotein in cervical cancer remains inconclusive. This study investigated the efficacy of hLF on the inhibition of U14 cervical cancer in vivo. Recombinant adenovirus carrying hLF (Ad-hLF) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1776
更新日期:2014-03-01 00:00:00
abstract::In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1763
更新日期:2014-03-01 00:00:00
abstract::Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1762
更新日期:2014-03-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are enzymes for extracellular matrix remodeling that are involved in tumor growth, progression and metastasis. Among them, MMP-9 has been implicated in tumor angiogenesis. Tissue inhibitor of matrix metalloproteinase (TIMP)-2, a member of the family of MMP inhibitors, induces apoptosis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1767
更新日期:2014-03-01 00:00:00
abstract::The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1792
更新日期:2014-03-01 00:00:00
abstract::The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1720
更新日期:2014-02-01 00:00:00
abstract::Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1739
更新日期:2014-02-01 00:00:00
abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1725
更新日期:2014-02-01 00:00:00
abstract::Tricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1726
更新日期:2014-02-01 00:00:00
abstract::Poor nutritional status is common in ovarian cancer. It is well known that the nutritional status of a patient with malignant disease is associated with survival, and that it can be assessed by serum levels of rapid turnover proteins (RTPs), such as retinol binding protein, prealbumin and transferrin. Systemic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1735
更新日期:2014-02-01 00:00:00
abstract::The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1744
更新日期:2014-02-01 00:00:00
abstract::The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1694
更新日期:2014-01-01 00:00:00
abstract::The aim of the present study was to determine the impact of obesity on radiation-induced gastrointestinal (GI) and genitourinary (GU) toxicity. The cases of 54 patients with prostate cancer, treated with three-dimensional conformal radiation therapy (RT), were reviewed. For each patient, the body mass index (BMI), dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1658
更新日期:2014-01-01 00:00:00
abstract::The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1676
更新日期:2014-01-01 00:00:00
abstract::A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1654
更新日期:2014-01-01 00:00:00
abstract::In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1660
更新日期:2014-01-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a process by which cancer cells acquire mesenchymal properties, such as induction of vimentin, while epithelial-associated genes like E-cadherin are lost. This enables cells to be more metastatic. Factors that are able to induce EMT include growth factors such as transforming...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1635
更新日期:2013-12-01 00:00:00
abstract::PX-12, as an inhibitor of thioredoxin (Trx), has antitumor activity. However, little is known about the toxicological effect of PX-12 on cervical cancer cells. In the present study, the growth inhibitory effects of PX-12 on HeLa cervical cancer cells in association with reactive oxygen species (ROS) and glutathione (G...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1637
更新日期:2013-12-01 00:00:00
abstract::Gastric cancer is a pathological process of an accumulation of multigene and multistage mutations. A new gene segment, MDSCBC11, has been previously obtained using a gene chip and is negatively associated with gastric cancer. The present study aimed to clone the full cDNA sequence of the MDSCBC11 segment and to detect...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1595
更新日期:2013-12-01 00:00:00
abstract::The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1608
更新日期:2013-12-01 00:00:00
abstract::Xeroderma pigmentosum variant (XP-V) is a subtype of xeroderma pigmentosum (XP) disease with typical pigmentation and types of cancer in the oral maxillofacial and other sun-exposed regions. Few factors of tumor proneness in XP-V have been completely elucidated with the exception of the POLH [which encodes DNA polymer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1604
更新日期:2013-12-01 00:00:00
abstract::The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benig...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1590
更新日期:2013-12-01 00:00:00
abstract::Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1566
更新日期:2013-11-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1556
更新日期:2013-11-01 00:00:00